Autologous Exosomes and Rapid Stem Cell Isolation

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    • ABOUT US
    • RESEARCH
    • OUR TECHNOLOGY
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  • ABOUT US
  • RESEARCH
  • OUR TECHNOLOGY
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OUR TECHNOLOGY

R3 = Regeneration, Reconstruction and Rejuvenation

R3GEN is uniquely positioned to leverage a diverse but synergistic IP portfolio in key areas of growth within Regenerative Medicine and Aesthetic Cosmetic Plastic and Reconstructive Surgery. 


Stem Cell Isolation Patent – Most isolation and tissue processing systems do not take into consideration the relative percentages of cell types, thus creating a "backup" or clogging of the capture system.  This lack of efficiency ultimately leads to a "skewed" profile, thus affecting cytokine and exosome profiles collected.  The autocorrection effect of this patent is crucial to obtaining a "natural" regenerative profile for both cells preserved and exosomes collected.

https://patentimages.storage.googleapis.com/da/51/80/77ff413c9ee469/US8283169.pdf


Exosome Isolation Patent – There is good and bad in everyone and everything including exosomes.  This patent covers multiple methods of collecting "good" exosomes for therapeutic and research use.  Further subpopulations and discrete miRNA types can be isolated using this powerful methodology.  This early dated seminal patent covers both methods and systems for foundational exosome processing necessary for any therapeutic use.  https://patentimages.storage.googleapis.com/0f/05/06/1c69969840ec3c/WO2014078420A1.pdf

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"...it is now widely established that the more immediate principle mechanism of action of MSCs in vivo is paracrine in nature, and that the generation of exosomes and microvesicles by MSCs is a critical parameter in their ability to modify the function of host cells and tissues." Stem Cells 2017; 35: 851-858

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